Growth Hormone-Releasing Hormone (GH-RH)
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Growth Hormone Releasing Hormone is a 44 amino acid peptide produced primarily by the hypothalamus. It is a neurohumoral control for adenohypophyseal secretion of Growth Hormone. Other hypothalamic hormones have a stimulatory effect on pituitary hormones, but Growth Hormone Releasing Hormone has no known effect on other pituitary hormones. Somatostatin is the inhibitory counterpart of Growth Hormone Releasing Hormone. Growth Hormone Releasing Hormone has structural similarities with the Secretin-Glucagon family of gastrointestinal hormones. Growth Hormone Releasing Hormone has been isolated from pancreatic islet cells and various cancer tumor cells.
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
Levels of IR-GH-RH
Baseline range: 5 - 18 pg/mL
Levels in GH-RH Dysfunction:
Patients with acromegaly: up to 200 pg/mL
Patients with small cell lung carcinoma: up to 50 pg/mL
GH-RH secreting tumors: 200 -10,000 pg/mL
This test was performed using a kit that has not been cleared or approved by the FDA and is designated as research use only.
The analytic performance characteristics of this test have been determined by Inter Science Institute. This test is not intended for diagnosis or patient management decisions without confirmation by other medically established means.