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Interpretive Handbook

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Test 9066:
Coagulation Factor X Activity Assay, Plasma

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Factor X is a vitamin K-dependent serine protease that is synthesized in the liver. Its biological half-life is 24 to 48 hours. Factor X participates in both intrinsic and extrinsic pathways of coagulation (final common pathway) by serving as the enzyme (factor Xa) in the prothrombinase complex.

 

Congenital factor X deficiency is rare. Acquired deficiency associated with liver disease, warfarin therapy, vitamin K deficiency, systemic amyloidosis and inhibitors (rare). Deficiency may cause prolonged prothrombin time and activated partial thromboplastin time.

Useful For Suggests clinical disorders or settings where the test may be helpful

Diagnosing deficiency of coagulation factor X, congenital or acquired

 

Evaluating hemostatic function in liver disease

 

Investigation of prolonged prothrombin time or activated partial thromboplastin time

Interpretation Provides information to assist in interpretation of the test results

Acquired deficiency more common than congenital

 

Homozygotes: <25%

 

Heterozygotes: 25% to 50%

Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

Liver disease, warfarin therapy, or vitamin K deficiency may lower factor X levels.

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

Adults: 70-150%

Normal, full-term newborn infants or healthy premature infants may have decreased levels (> or =15-20%) which may not reach adult levels for > or =180 days postnatal.*

*See Pediatric Hemostasis References in Coagulation Studies in Special Instructions.

Clinical References Provides recommendations for further in-depth reading of a clinical nature

1. Girolami A, Scandellari R, Scapin M, Vettore S: Congenital bleeding disorders of the vitamin K-dependent clotting factors. Vitam Horm 2008;78:281-374

2. Brenner B, Kuperman AA, Watzka M, Oldenburg J: Vitamin K-dependent coagulation factors deficiency. Semin Thromb Hemost 2009 Jun;35(4):439-446

3. Menegatti M, Peyvandi F: Factor X deficiency. Semin Thromb Hemost 2009 Jun;35(4):407-415

4. Girolami A, Ruzzon E, Tezza F, et al: Congenital FX deficiency combined with other clotting defects or with other abnormalities: a critical evaluation of the literature. Haemophilia 2008;14(2):323-328

5. Girolami A, Scarparo P, Scandellari R, Allemand E: Congenital factor X deficiencies with a defect only or predominantly in the extrinsic or in the intrinsic system: a critical evaluation. Am J Hematol 2008;83(8):668-671