Bone Histomorphometry, Gross Microscopic Exam
Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test
Bone histomorphometry is a very sophisticated procedure utilizing full-thickness bone biopsy.
Techniques such as 2 time-interval labeling with tetracycline permit the direct measurement of the rate of bone formation. The information derived is useful in the diagnosis of metabolic bone diseases, including renal osteodystrophy, osteomalacia, and osteoporosis, and other disorders such as aluminum toxicity and iron abnormalities.
Undetermined metabolic bone disease
Assessing effects of therapy
Identification of some disorders of the hematopoietic system
Presence of iron in the bone
Computer-generated histomorphometric values are given for adequate specimens.
Normal histomorphometric values for iliac crest are provided (female only).
An interpretive report is provided.
Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances
Decalcified bone is not acceptable for histomorphometric analysis.
Mineralization or bone formation rates can be done only when tetracycline has been administered on a specific schedule prior to biopsy.
The use of metal-free containers is required to avoid aluminum or iron contamination.
It is preferred that the specimen is shipped in 70% ethanol because it preserves the tetracycline label in the bone.
Biopsy site of preference is iliac crest.
Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.
The laboratory will provide a quantitative and an interpretive report.
The report will be sent to the physician designated on the Bone Histomorphometry: Patient Information.
Clinical References Provides recommendations for further in-depth reading of a clinical nature
Recker RR: Bone Histomorphometry: Techniques and Interpretation. Boca Raton, FL, CRC Press, 1983