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Interpretive Handbook

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Test 88897:
B-Cell Lymphoma, FISH, Blood or Bone Marrow

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Lymphoid neoplasms are known to be complex and the prognosis and clinical course of patients with lymphoma is highly variable. Genetic abnormalities have emerged as 1 of the most reliable criteria for categorizing lymphomas. Several chromosome anomalies and variants of these anomalies have been associated with various kinds of lymphoma (see Table). 

Common chromosome anomalies in lymphomas

Lymphoma Type

Chromosome Anomaly

FISH Probe

Burkitt

t(8;14)(q24;q32)

MYC/IGH

t(8;22)(q24;q11.2)

MYC/IGL

t(22;var)(q11.2;var)

IGL

Mantle cell

t(11;14)(q13;q32)

CCND1-XT/IGH

Follicular

t(14;18)(q32;q21)

IGH/BCL2

Diffuse large B-cell

t(3;var)(q27;var)

BCL6

t(14;18)(q32;q21)

IGH/BCL2

t(8;14)(q24;q32)

MYC/IGH

t(8;22)(q24;q11.2)

MYC/IGL

t(22;var)(q11.2;var)

IGL

Marginal zone of

MALT type

t(11;18)(q21;q21)

BIRC3/MALT1

t(14;18)(q32;q21)

IGH/MALT1

Useful For Suggests clinical disorders or settings where the test may be helpful

Detecting an abnormal clone associated with the common chromosome anomalies seen in patients with B-cell lymphoma, specifically Burkitt, mantle cell, follicular, diffuse large B-cell, and MALT lymphoma

 

Individual probes can also be utilized to identify specific chromosome anomalies in patients with B-cell lymphoma and track the response to therapy.

Interpretation Provides information to assist in interpretation of the test results

A neoplastic clone is detected when the percent of cells with an abnormality exceeds the normal reference range for any given probe.

 

The absence of an abnormal clone does not rule the presence of neoplastic disorder.

Cautions Discusses conditions that may cause diagnostic confusion, including improper specimen collection and handling, inappropriate test selection, and interfering substances

This test is not approved by the FDA and it is best used as an adjunct to existing clinical and pathologic information.

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

An interpretive report will be provided.

Clinical References Provides recommendations for further in-depth reading of a clinical nature

1. Remstein ED, Kurtin PJ, Buno I, et al: Diagnostic utility of fluorescence in situ hybridization in mantle-cell lymphoma. Br J Haematol 2000 Sep;110(4):856-862

2. Remstein ED, Kurtin PJ, James CD, et al: Mucosa-associated lymphoid tissue lymphomas with t(11;18) (q21;q21) and mucosa-associated lymphoid tissue lymphomas with aneuploidy develop along different pathogenetic pathways. Am J Pathol 2002 Jul;161(1):63-71

3. Remstein ED, Dogan A, Einerson RR, et al: The incidence and anatomic site specificity of chromosomal translocations in primary extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) in North America. Am J Surg Pathol 2006 Dec;30(12):1546-1553H636