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Interpretive Handbook

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Test 90429:
Angiotensin I, Plasma

Clinical Information Discusses physiology, pathophysiology, and general clinical aspects, as they relate to a laboratory test

Angiotensin I is a ten amino acid peptide formed by Renin cleavage of

Angiotensinogen (Renin Substrate). Angiotensin I has little biological

activity except that high levels can stimulate Catecholamine production.

It is metabolized to its biologically  active byproduct Angiotensin II by

Angiotensin Converting Enzyme (ACE). The formation of Angiotensin I is

controlled by negative feedback of Angiotensin II and II on Renin

release and by Aldosterone concentration. Levels of Angiotensin I are

increased in many types of hypertension. Angiotensin I levels are used

to determine Renin activity. Angiotensin I is excreted directly into the

urine.

Reference Values Describes reference intervals and additional information for interpretation of test results. May include intervals based on age and sex when appropriate. Intervals are Mayo-derived, unless otherwise designated. If an interpretive report is provided, the reference value field will state this.

Up to 25 pg/mL

 

This test was performed using a kit that has not been cleared or

approved by the FDA and is designated as research use only.

The analytic performance characteristics of this test have been

determined by Inter Science Institute. This test is not intended for

diagnosis or patient management decisions without confirmation

by other medically established means.

 

Test Performed by: Inter Science Institute

                                       944 West Hyde Park Blvd.

                                       Inglewood, CA 90302