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Anaplasma phagocytophilum is a tick-borne agent that causes an acute febrile illness that often resembles Rocky Mountain Spotted Fever.
Anaplasma phagocytophilum is the tick-borne agent causing Human Granulocytic Ehrlichiosis (HGE). HGE is distinct and separate from Human Monocytic Ehrlichiosis (HME), caused by Ehrlichia chaffeensis. Serologic crossreactivity between A. phagocytophilum and E. chaffeensis is minimal (5-15%).