Coagulation Testing Quality
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Conference and Workshop
3rd Conference
April 14-17, 2009 (Tuesday-Friday) [ends at Noon Friday]
1st Workshop
April 15-16, 2009 (Wednesday & Thursday Afternoons)
Minneapolis Marriott City Center Hotel
Minneapolis, Minnesota
Presented by:
- Mayo Clinic Divisions of Hematology and Hematopathology
- Mayo Medical Laboratories
- North American Specialized Coagulation Laboratory Association (NASCOLA)
Conference Description
This conference provides a unique international forum for communication and discussion of current issues in quality and standardization of coagulation diagnostic laboratory testing. Continued conference features include abstract presentations (oral and poster) and Breakfast-with-the-Experts sessions. There will also be presentations by expert faculty on a wide range of topics, along with panel discussions and question and answer sessions.
Conference Learning Objectives
Upon completion of the conference, participants should be able to:
- Describe general aspects of planning and management of coagulation laboratory testing
- Provide examples of processes and goals of quality assessment and improvement processes
- Discuss the complexities of testing for disorders of platelets and platelet function
- Summarize testing quality issues for diagnosis and treatment of von Willebrand disease
- Review the diagnostic and quality challenges associated with testing for factor VIII inhibitors
Workshop Description
New this year - Two workshop sessions will be conducted Wednesday and Thursday afternoons. The first will be focused on testing for platelet functional disorders, and the second will focus on testing for selected plasmatic coagulation disorders. Each workshop session will begin with participating companies presenting information on specific laboratory instrument and/or reagent testing. Interactive case studies by conference faculty on thematic topics will conclude each workshop session.
Workshop Learning Objectives
Upon completion of the workshop, participants should be able to:
- Comprehend the role of the coagulation diagnostics industry in achieving high-quality testing
- Provide specific examples of platelet hypofunctional disorders and testing procedures for them
- Recount examples of specific complex coagulation disorders and quality of diagnostic testing
Disclaimer
Attendance at this Mayo conference does not indicate nor guarantee competence or proficiency in the performance of any procedures that may be discussed or taught in this course.
Intended Audience
This conference is designed for laboratorians, hematologists, pathologists, scientists, laboratory technologists, and clinicians whose practices and interests include laboratory and clinical aspects of bleeding and prothrombotic disorders.
Date and Location
The Coagulation Testing Quality conference will be held April 14-17, 2009 and the workshop on the afternoons of April 15-16, 2009. The conference will be located in the Minneapolis Marriott City Center Hotel (4th floor) in downtown Minneapolis, Minnesota.
Credit
Conference
The College of Medicine, Mayo Clinic is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians, and designates this educational activity for a maximum of 18 hours of AMA PRA Category 1 CreditTM. Physicians should only claim credit commensurate with the extent of their participation in the activity.
Mayo Medical Laboratories is approved as a provider of continuing education programs in the Clinical Laboratory Sciences by the ASCLS P.A.C.E.® program. This program has been approved for 18 P.A.C.E. contact hours. Level of instruction for this program is intermediate.
Mayo Medical Laboratories is approved as a Continuing Education Accrediting Agency for Clinical Laboratory Science for State of California and State of Florida credit. The level of instruction for this program is intermediate. This program has been approved for 18 contact hours.
Workshop
**Due to the nature of the Wednesday and Thursday afternoon workshops and the interactions from industry, Category 1 credit will only be provided for the case studies. The College of Medicine, Mayo Clinic is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians, and designates this educational activity for a maximum of 3 hours of AMA PRA Category 1 CreditTM. Physicians should only claim credit commensurate with the extent of their participation in the activity.
Mayo Medical Laboratories is approved as a provider of continuing education programs in the Clinical Laboratory Sciences by the ASCLS P.A.C.E.® program. This program has been approved for 2.5 P.A.C.E. contact hours. Level of instruction for this program is intermediate.
Mayo Medical Laboratories is approved as a Continuing Education Accrediting Agency for Clinical Laboratory Science for State of California and State of Florida credit. The level of instruction for this program is intermediate. This program has been approved for 2.5 contact hours.
Educational Grants
This course is supported, in part, by educational grants from coagulation-related diagnostics and therapeutics corporations, in accordance with ACCME Standards.
At the time of this publication, a complete listing of commercial supporters was not available. Appropriate acknowledgement will be given to all supporters during the meeting.
Abstracts
As part of the Coagulation Testing Quality conference, participants are invited to submit abstracts for oral or poster presentation, demonstrating new information related to laboratory diagnostic aspects of hemostatic disorders (bleeding and thrombosis). Goals of the abstract presentations are to educate and inform about research innovations, share ideas and interests, and network with other participants. Conference scholarships (reduced registration fee) will be offered to the top 5 accepted abstracts from technologist presentors (submitted abstracts will be reviewed and ranked by a committee).
Questions regarding abstract submission can be directed to Sharon Preuss at 507-284-8742. Abstracts must be received by Monday, February 23, 2009 for consideration by the review committee, and decisions will be communicated by Monday, March 9, 2009.
- Call for Abstracts
- Abstract submission guidelines
- Abstract submission Form
Faculty
Course Director
William L. Nichols, MD
Consultant, Laboratory Medicine and Hematology/Internal Medicine
Mayo Special Coagulation Laboratory and Coagulation Clinical Centers
Co-Director, Coagulation Education Programs
Director, Mayo International Hemophilia Training Center (WFH)
Associate Professor, Medicine and Laboratory Medicine*
Course Co-Directors
Rajiv K. Pruthi, MBBS
Consultant, Hematology/Internal Medicine and Laboratory Medicine
Mayo Special Coagulation Laboratory and Coagulation Clinical Centers
Co-Director, Mayo Special Coagulation DNA Diagnostic Laboratory
Co-Director, Coagulation Clinical and Laboratory Practice
Director, Mayo Comprehensive Hemophilia Center
Assistant Professor, Medicine*
Catherine P.M. Hayward, MD, PhD
President, North American Specialized Coagulation Laboratory Association
Head, Coagulation Laboratories
Hamilton Regional Laboratory Medicine Program
Professor, Pathology & Molecular Medicine, and Medicine
McMaster University Medical Centre
Hamilton, Ontario, Canada
Mayo Clinic Faculty
Layna K. Cardel, BS, MT(ASCP)
Education Specialist
Mayo Special Coagulation Laboratory
Department of Laboratory Medicine and Pathology
Instructor, Laboratory Medicine*
Dong Chen, MD, PhD
Consultant, Mayo Hematopathology and Special Coagulation Laboratories
Department of Laboratory Medicine and Pathology
Assistant Professor, Laboratory Medicine and Pathology*
*College of Medicine, Mayo Clinic
Guest Faculty
Dorothy M. (Adcock) Funk, MD
Medical and Laboratory Director
Esoterix Coagulation
Aurora, Colorado
Wayne L. Chandler, MD
Director, Clinical Coagulation Laboratory
Professor and Vice-Chair
Department of Laboratory Medicine
University of Washington
Harborview Medical Center
Seattle, Washington
Marilyn A. Johnston, MLT, ART
Director
Hemostasis Reference Laboratory
Hamilton, Ontario, Canada
Steve Kitchen, PhD
Clinical Scientist
Sheffield Haemophilia and Thrombosis Center
Royal Hallamshire Hospital
Sheffield, England
Marlies R. Ledford-Kraemer, MBA, BS, MT(ASCP) SH
President, CLOT-ED, Inc.
130 North Rolling Hill Road
Islamorada, Florida
Richard A. Marlar, PhD
Director, Coagulation Laboratory
Chief, Clinical Pathology
Department of Pathology and Laboratory Medicine
Oklahoma Veterans Affairs Medical Center
Professor of Pathology
University of Oklahoma Health Sciences Center
Oklahoma City, Oklahoma
Piet Meijer, PhD
Executive Director, ECAT Foundation
Leiden, Netherlands
Karen A. Moffat. MLT, ART, FCSMLS(D)
Technical Specialist, Coagulation
Hamilton Regional Laboratory Medicine Program
Lecturer, Department of Medicine
McMaster University
Hamilton, Ontario, Canada
John D. Olson, MD, PhD
Director of Clinical Laboratories
Professor of Pathology and Vice Chair for Clinical Affairs
Department of Pathology
University of Texas Health Science Center
San Antonio, Texas
Ellinore I. Peerschke, PhD
Professor of Pathology
Associate Director for Clinical Laboratories
Chief, Division of Translational Research
Director, Coagulation and Microscopy Laboratories
Mount Sinai School of Medicine
New York, New York
Elizabeth A. Plumhoff, MT(ASCP), CLS(NCA)
Executive Secretary, North American Specialized Coagulation Association
Scientific Director, Editorial Publications
Mayo Collaborative Services, Inc.
Rochester, Minnesota
F. Eric Preston, MD
Director, WHO/WFH EQA Scheme for Blood Coagulation
Professor, Medicine
Department of Haematology
University of Sheffield
Sheffield, England
Anne Raby, MLT, ART
Hematology Consultant Technologist
External Quality Assessment
Quality Management Program - Laboratory Services
Toronto, Ontario, Canada
Georges E. Rivard, MD
Clinical Professor
Pediatrics and Hematology
Director
Hemophilia Clinic and Clinical Coagulation Laboratory
Centre Hospitalier Universitaire Sainte-Justine
Montreal, Quebec, Canada
Elizabeth M. Van Cott, MD
Director, Coagulation Laboratory
Massachusetts General Hospital
Associate Professor of Pathology
Harvard Medical School
Boston, Massachusetts
Bert Verbruggen, PhD
Haemostasis Laboratory
Central Haematology Laboratory
Radboud University, Nijmegen Medical Center
Nijmegen, Netherlands
James G. White, MD
Regents Professor, Pediatrics, Laboratory Medicine and Pathology
University of Minnesota, School of Medicine
Minneapolis, Minnesota
James L. Zehnder, MD
Director, Coagulation and Molecular Genetic Pathology Laboratories
Professor, Pathology & Medicine (Hematology)
Stanford University School of Medicine
Stanford, California
Faculty Disclosure
As a provider accredited by ACCME, College of Medicine, Mayo Clinic (Mayo School of CME) must ensure balance, independence, objectivity and scientific rigor in its educational activities. Course director(s), planning committee, faculty, and all others who are in a position to control the content of this educational activity are required to disclose all relevant financial relationships with any commercial interest related to the subject matter of the educational activity. Safeguards against commercial bias have been put in place. Faculty also will disclose any off-label and/or investigational use of pharmaceuticals or instruments discussed in their presentation. Disclosure of this information will be published in course materials so that participants in the activity may formulate their own judgments regarding the presentation.
Conference Agenda
Tuesday, April 14, 2009
| 7:00-8:00 AM | Registration and Breakfast Marriott Minneapolis City Center Hotel, 4th Floor Lobby |
| Session I: Quality in Laboratory Hemostasis and Thrombosis Moderator: John D. Olson, MD, PhD |
|
| 7:55-8:00 AM | Welcome and Introduction - Ballroom 1 William L. Nichols, MD |
| 8:00-8:30 AM | General Quality Planning in the Hemostasis Laboratory John D. Olson, MD, PhD |
| 8:30-9:00 AM | Hemostasis Test Validation, Performance and Reference Intervals Richard A. Marlar, PhD |
| 9:00-9:30 AM | Sample Integrity and Preanalytical Variables Dorothy M. (Adcock) Funk, MD |
| 9:30-10:00 AM | Internal Quality Control in the Hemostasis Laboratory Steve Kitchen, PhD |
| 10:00-10:30 AM | Break (Exhibits Open) |
| 10:30-11:00 AM | External Quality Assessment in Hemostasis: Its Importance and Significance F. Eric Preston, MD |
| 11:00-11:30 AM | Initial Evaluation of Hemostasis: Reagent and Method Selection Wayne L. Chandler, MD |
| 11:30-12:15 PM | Questions and Panel Discussion Faculty |
| 12:15-1:45 PM | Luncheon Marriott Ballroom 2 |
Session II: Laboratory Quality Organizations: Updates About New Initiatives and Programs
Moderator: Piet Meijer, PhD
| 1:45-2:05 PM | EQATH: Passing and Failing PT/EQA – Results of an EQATH Survey John D. Olson, MD, PhD |
| 2:05-2:25 PM | QMP-LS: A Canadian Regional EQA Program – How Labs Get In and Out of Trouble in Ontario Anne Raby, MLT, ART |
| 2:25-2:45 PM | ECAT: New EQA Initiatives – Factor XIII, Fibrinolysis, Heparin Piet Meijer, PhD |
| 2:45-3:05 PM | UK-NEQAS: What’s New? - EQA for Heparin-Induced Thrombocytopenia (HIT) Testing and LMWH (Low Molecular Weight Heparin) Assays Steve Kitchen, PhD |
| 3:05-3:35 PM | Break (Exhibits Open) |
| 3:35-3:55 PM | NASCOLA’s New Studies and Initiatives – Burning Questions, and Networking to Find Answers Catherine P.M. Hayward, MD, PhD |
| 3:55-4:15 PM | CLSI: Highlights of New Guidelines for Hemostasis Testing |
| 4:15-4:35 PM | CAP: Results from New EQA Initiatives – HIT, Heparin, Thrombophilia Elizabeth M. Van Cott, MD |
| 4:35-5:15 PM | Panel Discussion and Questions |
| 5:15 PM | Adjourn |
| 6:00-8:00 PM | Conference Reception with Hemostasis Product Display and Poster Viewing Marriott Fourth Floor Lobby |
Wednesday, April 15, 2009
| 7:00-8:30 AM | Breakfast Marriott Fourth Floor Lobby |
| 7:30-8:30 AM | Breakfast-with-the-Experts (Simultaneous sessions, repeated on Thursday; pre-registration required) Session 1: Pediatric Hemostatic Disorders and Testing: A Case-Based Discussion - Crystal Lake Room Session 2: Heparin-Induced Thrombocytopenia (HIT) and Laboratory Testing - Ballroom 1 Session 3: Optimizing Testing for Platelet Disorders – The Nitty Gritty of What We Do - Deer Lake Room Session 4: Validating New or Revised Diagnostic Tests - Elk Lake Room |
| 8:40 AM | Announcements and Updates - Ballroom 1 |
Session III: Platelet Functional Disorders and Testing
Moderator: James L. Zehnder, MD
| 8:45-9:30 AM | Platelet Electron Microscopy for Diagnosis of Platelet Disorders James G. White, MD |
| 9:30-10:00 AM | NASCOLA / ECAT Platelet Aggregometry Interpretive Survey and Proficiency Exercise for Dense Granule Deficiency Evaluation Catherine P.M. Hayward, MD, PhD |
| 10:00-10:30 AM | Flow Cytometry for Evaluation of Platelet Disorders Dong Chen, MD, PhD |
| 10:30-11:00 AM | Break (Exhibits and Posters Open) |
| 11:00-11:30 AM | Heparin-Induced Thrombocytopenia (HIT) Laboratory Testing: Results of a New ECAT EQA Initiative Piet Meijer, PhD |
| 11:30-12:00 PM | Panel Discussion and Questions |
| 12:00-1:30 PM | Luncheon |
Session IV: Coagulation Workshop 1: Platelet Functional Disorders and Testing
SPRING TRAINING: Instrument & Reagent Presentations (Pre-registration Required)
Moderator: William L. Nichols, MD
Presentations by Platelet-related Diagnostics/Instruments/Reagents Companies (Companies to provide speaker)
| 1:30 PM | Workshop Opening Comments William L. Nichols, MD |
| 1:35-2:00 PM | Whole Blood Platelet Aggregation in Clinical Practice |
| 2:00-2:25 PM | PFA-100 Testing: Clinical Indications Donna D. Castellone, MS, MT(ASCP)SH Clinical Project Manager Hemostasis/Hematology Siemens Healthcare Diagnostics Tarrytown, New York Sponsored by Siemens Healthcare Diagnostics |
| 2:25:2:40 PM | The Technique of Platelet Whole Mount Electron Microscopy for Dense Granule Enumeration: A Video Demonstration James G. White, MD |
| 2:40-2:50 PM | Panel Discussion and Questions |
| 2:50-3:30 PM | Break (Exhibits and Posters Open) |
Workshop: Case-based testing & clinical presentations
Moderator: William L. Nichols, MD
(Faculty Presentations)
| 3:30-4:00 PM | Case A Catherine P.M. Hayward, MD, PhD |
| 4:00-4:30 PM | Case B William L. Nichols, MD |
| 4:30-5:00 PM | Case C Dong Chen, MD, PhD |
| 5:00 PM | Adjourn (No pre-scheduled evening conference activities) |
Thursday, April 16, 2009
| 7:00-8:30 AM | Breakfast Marriott Fourth Floor Lobby |
| 7:30-8:30 AM | Breakfast-with-the-Experts (Simultaneous sessions, repeated from Wednesday; pre-registration required) Session 1: Pediatric Hemostatic Disorders and Testing: A Case-Based Discussion - Crystal Lake Room Session 2: Heparin-Induced Thrombocytopenia (HIT) and Laboratory Testing - Ballroom 1 Session 3: Optimizing Testing for Platelet Disorders – The Nitty Gritty of What We Do - Deer Lake Room Session 4: Validating New or Revised Diagnostic Tests - Elk Lake Room |
| 8:40 AM | Announcements and Updates - Ballroom 1 |
Session V: Von Willebrand Factor/Disease (VWF/VWD) and Factor VIII Inhibitors
Moderator: Ellinor I.B. Peerschke, PhD
| 8:45-9:10 AM | Laboratory Diagnosis of VWD: The 2008 NHLBI Guidelines William L. Nichols, MD |
| 9:10-9:30 AM | VWF/VWD Testing Practices: NASCOLA Survey Results Wayne L. Chandler, MD |
| 9:30-10:00 AM | Clinical and Laboratory Aspects of Factor VIII Inhibitors: An Overview Georges E. Rivard, MD |
| 10:00–10:30 AM | Break (Exhibits and Posters Open) |
| 10:30–11:00 AM | Factor VIII Inhibitor Testing: Nijmegen Modifications, Experience and Recommendations Bert Verbruggen, PhD |
| 11:00-11:20 AM | Factor VIII Inhibitor Evaluation: Mayo Clinic Approach & New Information Rajiv K. Pruthi, MBBS |
| 11:20-11:35 AM | NASCOLA Proficiency Testing Results for Factor VIII Inhibitors Ellinor I.B. Peerschke, PhD |
| 11:35-12:10 PM | Panel Discussion and Questions |
| 12:10-1:30 PM | Luncheon Marriott Ballroom 2 |
Session VI: Coagulation Workshop 2: Coagulation Disorders and Testing
Spring Training: Instrument & reagent presentations (Pre-registration Required)
Moderator: Rajiv K. Pruthi, MBBS
Presentations by Coagulation-related Diagnostics/Instruments/Reagents Companies (Companies to provide speaker)
| 1:30 PM | Workshop Opening Comments Rajiv K. Pruthi, MBBS |
| 1:35-2:00 PM | Innovations in Monitoring Anticoagulant Therapies Jim F. DeMase Marketing Manager - Hemostasis Beckman Coulter, Inc. Brea, California Sponsored by Beckman Coulter / Instrumentation Laboratory |
| 2:00-2:25 PM | New Technologies in Coagulation from GTI Diagnostics: VWF & Propeptide Assay & FVIII Antibody Screen Dave Boyer Product Manager - New Technology Assessment GTI Diagnostics Waukesha, Wisconsin Sponsored by GTI Diagnostics |
| 2:25-2:50 PM | Procoagulant Phospholipid Gwyn A. Cutsforth, MT(ASCP), PhD Clinical & Scientific Research Manager Diagnostica Stago, Inc. Parsippany, New Jersey Sponsored by Diagnostica Stago, Inc. |
| 2:50-3:00 PM | Panel Discussion and Questions |
| 3:00-3:30 PM | Break (Exhibits and Posters Open) |
Workshop: Case-based testing & clinical presentations
Moderator: Rajiv K. Pruthi, MBBS (Faculty Presentations)
| 3:30-4:00 PM | Case A Rajiv K. Pruthi, MBBS |
| 4:00-4:30 PM | Case B Layna K. Cardel, BS, MT(ASCP) |
| 4:30-5:00 PM | Case C Elizabeth M.Van Cott, MD |
| 5:00 PM | Adjourn (No pre-scheduled evening conference activities) |
Friday, April 17, 2009
| 6:45-7:55AM | Breakfast (Marriot 4th Floor) |
Session VII: Coagulation Testing Potpourri
Moderator: Dong Chen, MD, PhD
| 7:55 AM | Announcements - Ballroom 1 |
| 8:00-8:30 AM | External Quality Assessment of Point-of-Care Testing (POCT) Devices in Hemostasis Including ACT, ROTEM and TEG Steve Kitchen, PhD |
| 8:30-8:45 AM | Abstract #1: Evaluation of the Haemonetics TEG® 5000 Platelet Mapping™ Method Suzanne M. Hoffman, MT(ASCP) Special Coagulation Laboratory University of Wisconsin Hospital and Clinics Madison, Wisconsin |
| 8:45-9:15 AM | EQA Assessment Incorporating Biological Variation Piet Meijer, PhD |
| 9:15-9:30 AM | Abstract #2: A Regional Quality Assurance Program for Core Coagulation Laboratories Karen A. Moffat, MLT, ART, FCSMLS(D) |
| 9:30-10:00 AM | D-Dimer Assay Issues and Standardization: QMP-LS Studies Anne Raby, MLT, ART |
| 10:00-10:30 AM | Break |
| 10:30-11:00 AM | Laboratory Monitoring of Heparin Anticoagulation: Current Issues and Recommendations Marilyn A. Johnston, MLT, ART |
| 11:00-11:15 AM | Abstract #3: Evaluation of an Alternate Activating Reagent for the Performance of Coagulation Factor Assays in the Presence of Lupus Anticoagulants John Barranco, MT(ASCP) Florida Hospital Center for Thrombosis Research Orlando, Florida |
| 11:15-11:30 AM | Abstract #4: Laboratory Evaluation of an Automated Latex von Willebrand Factor Activity Assay Julie I. Tange, BS Special Coagulation Laboratory Mayo Clinic Rochester, Minnesota |
| 11:30-12:00 PM | Panel Discussion and Questions |
| 12:00 PM | Adjourn (Box lunches available) |
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