August 13-15, 2008

Description

This 13th Mayo coagulation conference will provide reviews and updates about laboratory and clinical aspects of bleeding and thrombosing disorders. Didactic presentations will be supplemented with panel discussions and case presentations. Adequate time will be allocated for questions. New features for 2008 include: 1) Four Breakfast-with-the-Experts interactive educational sessions (repeated Thursday and Friday mornings); 2) Conference length extended from 2 to 2.5 days, adjourning Friday noon.

Learning Objectives

Upon completion of the conference participants should be able to:

• Describe mechanisms and control of hemostasis
• Assess common disorders of hemostasis that lead to bleeding or thrombosis
• Recognize rarer disorders of hemostasis
• Explain laboratory evaluation of bleeding or thrombosing diatheses
• Interpret screening and more complex tests of hemostasis
• Evaluate antibody-mediated prothrombotic disorders such as heparin-induced thrombocytopenia, thrombotic thrombocytopenic purpura, or lupus anticoagulant and antiphospholipid syndrome
• Discuss prevention or treatment of bleeding and thrombosis
• Summarize principles of oral anticoagulant therapy and monitoring

Attendance at this Mayo course does not indicate nor guarantee competence or proficiency in the performance of any procedures which may be discussed or taught in this course.

Intended audience

This program is designed for clinicians, pathologists, scientists, and laboratory technologists whose practices include bleeding and thrombosing diseases.

Date and Location

The Bleeding and Thrombosing Diseases conference will be held August 13-15, 2008 (Wednesday, Thursday and Friday). Course headquarters will be located in Heritage Hall on the lower level of The Kahler Grand Hotel, 20 Second Avenue SW, Rochester, Minnesota. Meeting facilities are easily accessible by skyway and pedestrian subway, which connect to shops, theaters, restaurants, and hotels.

Credit

The College of Medicine, Mayo Clinic is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians, and designates this educational activity for a maximum of 16.5 hours of AMA PRA Category 1 Credit^TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

Mayo Medical Laboratories is approved as a provider of continuing education programs in the Clinical Laboratory Sciences by the ASCLS P.A.C.E.^® Program. This program has been approved for 16.5 P.A.C.E. contact hours. Level of instruction for this program is intermediate.

Mayo Medical Laboratories is approved as a Continuing Education Accrediting Agency for Clinical Laboratory Science for State of California and State of Florida credit. The level of instruction for this program is intermediate. This program has been approved for 16.5 contact hours.

Educational Grants

This course is supported, in part, by educational grants from coagulation-related diagnostics and therapeutics corporations, in accordance with ACCME Standards.

At the time the site was posted , a complete listing of commercial supporters was not available. Appropriate acknowledgment will be given to all supporters at the time of the meeting.

Conference Faculty

Course Director

William L. Nichols, MD
Consultant, Laboratory Medicine and Hematology/Internal Medicine
Mayo Special Coagulation Laboratory and Coagulation Clinical Centers
Co-Director, Coagulation Education Programs
Director, Mayo International Hemophilia Training Center (WFH)
Associate Professor, Medicine and Laboratory Medicine*

Course Co-Directors

Aneel A. Ashrani, MD
Consultant, Hematology/Internal Medicine and Coagulation
Mayo Special Coagulation Laboratory, Coagulation Clinical Centers and Thrombophilia Center
Assistant Professor, Medicine*

Rajiv K. Pruthi, MBBS
Consultant, Hematology/Internal Medicine and Laboratory Medicine
Mayo Special Coagulation Laboratory and Coagulation Clinical Centers
Co-Director, Mayo Special Coagulation DNA Diagnostic Laboratory
Co-Director, Coagulation Clinical and Laboratory Practice
Director, Mayo Comprehensive Hemophilia Center
Assistant Professor, Medicine*

Alexandra P. Wolanskyj, MD
Consultant, Hematology/Internal Medicine and Coagulation
Education Chair, Division of Hematology and Internal Medicine
Assistant Professor, Medicine*

Mayo Rochester Faculty

Linnea M. Baudhuin, PhD
Consultant, Laboratory Medicine and Medical Genetics
Co-Director, Cardiovascular Laboratory Medicine
Co-Director, Nucleotide Polymorphism Laboratory
Assistant Professor, Laboratory Medicine and Pathology*

Dong Chen, MD, PhD
Consultant, Hematopathology and Special Coagulation Laboratories
Assistant Professor, Laboratory Medicine and Pathology*

Michelle A. Elliott, MD
Consultant, Hematology and Coagulation
Assistant Professor, Medicine*

John A. Heit, MD
Consultant, Cardiovascular Medicine, Hematology and Laboratory Medicine
Director, Mayo Coagulation Laboratories/Clinics and Coagulation Group
Professor, Medicine*

C. Christopher Hook, MD
Consultant, Hematology and Coagulation
Assistant Professor, Medicine*

Whyte G. Owen, PhD
Consultant, Hematology/Coagulation Research and Biochemistry
Professor, Biochemistry and Molecular Biology*

Animesh Pardanani, MBBS, PhD
Consultant, Hematology/Internal Medicine and Coagulation
Assistant Professor, Medicine*

Vilmarie Rodriquez, MD
Consultant, Pediatric Hematology/Oncology and Hemophilia
Assistant Professor, Pediatric and Adolescent Medicine*

Waldemar E. Wysokinski, MD
Consultant, Cardiovascular Diseases/Internal Medicine and Coagulation
Assistant Professor, Medicine*

*College of Medicine, Mayo Clinic

Guest Faculty

Catherine P.M. Hayward, MD, PhD
Head, Coagulation Laboratories
Hamilton Regional Laboratory Medicine Program
Professor, Pathology & Molecular Medicine, and Medicine
McMaster University
Hamilton, Ontario, Canada

Faculty Disclosure

As a provider accredited by ACCME, College of Medicine, Mayo Clinic (Mayo School of CME) must ensure balance, independence, objectivity and scientific rigor in its educational activities. Course director(s), planning committee, faculty, and all others who are in a position to control the content of this educational activity are required to disclose all relevant financial relationships with any commercial interest related to the subject matter of the educational activity. Safeguards against commercial bias have been put in place. Faculty also will disclose any off-label and/or investigational use of pharmaceuticals or instruments discussed in their presentation. Disclosure of this information will be published in course materials so that participants in the activity may formulate their own judgments regarding the presentation.

Conference Agenda

Wednesday, August 13, 2008

7:00–7:45 AM

Registration and Breakfast Heritage Hall Foyer, The Kahler Grand Hotel, Subway Level

Morning Session Chair: Rajiv K. Pruthi, MBBS

7:50–8:00 AM	Welcome and Announcements Heritage Hall, The Kahler Grand Hotel
8:00–8:10 AM	Commemorating Dr. E.J. Bowie (1925-2008) William L. Nichols, MD
8:10–9:00 AM	Dr. Walter Bowie Commemorative Lecture: The Basics of Hemostasis and Its Regulation Whyte G. Owen, PhD
9:00–9:30 AM	The Hemostatic History: The Most Important Test C. Christopher Hook, MD
9:30–10:15 AM	Platelet Function, Testing and Hereditary Disorders Catherine P.M. Hayward, MD, PhD
10:15–10:45 AM	Break (Exhibits Open)
10:45–11:30 AM	Von Willebrand Disease and von Willebrand Factor Michelle A. Elliott, MD
11:30 AM–Noon	Panel Discussion Faculty
Noon–1:30 PM	Luncheon (Exhibits Open 1:00-1:30PM)

Afternoon Session Chair: C. Christopher Hook, MD

1:30–2:00 PM	Hemophilia – Hereditary and Acquired: Update Aneel A. Ashrani, MD
2:00-2:30 PM	Evaluating Children for Bleeding Symptoms and Disorders Vilmarie Rodriguez, MD
2:30–3:00 PM	Hemostatic Disorders of Pregnancy C. Christopher Hook, MD
3:00–3:30 PM	Break (Exhibits Open)
3:30–4:15 PM	Evaluating Unexplained Clotting Time Prolongation (PT, APTT) Rajiv K. Pruthi, MBBS
4:15–5:00 PM	Panel Discussion and Case Presentations Faculty
6:30–8:30 PM	Conference Reception and Hemostasis Product Display (see Social Programs section for additional information) Windsor Hall Foyer and Windsor Hall, The Kahler Grand Hotel

Thursday, August 14, 2008

7:30–8:30 AM

Breakfast-with-the-Experts Sessions (Sessions are repeated Friday morning, August 15) Beyond the Normal PT and APTT: Case Based Diagnostics Using Other Hemostasis Tests Catherine P.M Hayward, MD, PhD Thrombophilia Case Studies John A. Heit, MD VWD Diagnosis and Management: The New NHLBI Guidelines William L. Nichols, MD Coagulation Laboratory and Clinical Case Potpourri Rajiv K. Pruthi, MBBS

Morning Session Chair: Michelle A. Elliott, MD

8:55-9:00 AM	Announcements and Introductory Comments Michelle A. Elliott, MD
9:00-9:30 AM	Flow Cytometric Evaluation of Platelet Function and Disorders Dong Chen, MD, PhD
9:30-10:10 AM	Heparin – Induced Thrombocytopenia (HIT) Rajiv K. Pruthi, MBBS
10:10-10:45 AM	Thrombotic Thrombocytopenic Purpura (TTP) Michelle A. Elliott, MD
10:45-11:15 AM	Break (Exhibits Open)
11:15-11:45 AM	Bleeding and Thrombosis with Myeloproliferative Syndromes Animesh Pardanani, MBBS, PhD
11:45-12:15 PM	Panel Discussion Faculty
12:15–1:45 PM	Luncheon (Exhibits Open 1:15-1:45PM)

Afternoon Session Chair: Alexandra P. Wolanskyj, MD

1:45-2:30 PM	Hereditary Rarer Plasmatic Bleeding Disorders Aneel A. Ashrani, MD
2:30-3:10 PM	Lupus Anticoagulants and the Antiphospholipid Syndrome William L. Nichols, MD
3:10–3:45 PM	Estrogens and Venous Thromboembolism Alexandra P. Wolanskyj, MD
3:45–4:15 PM	Break (Exhibits Open)
4:15–5:00 PM	Panel Discussion and Case Presentations Faculty

Friday, August 15, 2008

7:30–8:30 AM

Breakfast-with-the-Experts Sessions (Sessions are repeated from Thursday morning, August 14) Beyond the Normal PT and APTT: Case Based Diagnostics Using Other Hemostasis Tests Catherine P.M Hayward, MD, PhD Thrombophilia Case Studies John A. Heit, MD VWD Diagnosis and Management: The New NHLBI Guidelines William L. Nichols, MD Coagulation Laboratory and Clinical Case Potpourri Rajiv K. Pruthi, MBBS

Morning Session Chair: John A. Heit, MD

8:55-9:00 AM	Announcements and Introductory Comments John A. Heit, MD
9:00–9:45 AM	Thrombophilia Testing: Implications for Prevention and Management of Venous Thromboembolism John A Heit, MD
9:45–10:15 AM	Atypical Venous Thromboembolism Waldemar E. Wysokinski, MD
10:15-10:45 AM	Break
10:45–11:30 AM	Warfarin Pharmacogenetics: Ready for Clinical Utility? Linnea M. Baudhuin, PhD
11:30-Noon	Panel Discussion Faculty

Conference Conclusion