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Autoimmune Dysautonomia Evaluation

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ADE/89904 Autoimmune Dysautonomia Evaluation, Serum Algorithm

Slide 17

July 2012

The first is the immunofluorescence pattern is indeterminate.  In this situation there may be an antibody staining pattern suspicious for antineuronal nuclear antibody type-1 or ANNA-1, but not all of the characteristic features are present.  In that setting we will additionally do a paraneoplastic Western blot to look for the characteristic pattern associated with this antibody.  The second and third settings would occur where an antibody pattern suggestive of amphiphysin antibody or CRMP-5 IgG were detected.  Then we would confirm the presence of these antibodies with recombinant Western blots for the appropriate antibody either amphiphysin or CRMP-5 IgG.

ADE Algorithm

 


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