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The Use of Genetics in Guiding Therapy



HLA-B*5701

Slide 34

June 2012

Another HLA-B allele, *5701, is associated with hypersensitivity to the HIV drug abacavir. About 5% to 8% of AIDS patients develop a hypersensitivity reaction to abacavir. There is a strong association between HLA-B*5701 and abacavir hypersensitivity in Caucasians. It has been demonstrated that HLA-B*5701 screening can be used for risk stratification of patients when the HLAB*5701 allele is present, there is a high-risk for a hypersensitivity reaction to abacavir with a positive predictive value of approximately 58%. When the HLAB*5701 allele is absent, there is a low-risk for hypersensitivity reaction to abacavir with a negative predictive value of approximately 100%..

HLA-B*5701

 


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