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The Use of Genetics in Guiding Therapy


Slide 32

June 2012

The HLA-B*1502 allele is associated with hypersensitivity to carbamazepine, phenytoin, and fosphenytoin. Carbamazepine is an anticonvulsant, used to treat epilepsy, manic/bipolar disorders, and neuropathic pain. Hypersensitivity to carbamazepine is a leading cause of Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS/TEN). The HLA-B*1502 allele is positively correlated to carbamazepine-associated SJS/TEN, and occurs mainly in individuals of southeast Asian descent.



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