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The Use of Genetics in Guiding Therapy

Human Leukocyte Antigens and Drug Hypersensitivity

Slide 31

June 2012

Drug hypersensitivity affects approximately 7% of the general population and can manifest as a variety of non-specific and oftentimes serious side-effects. Almost all drugs can induce hypersensitivity reactions which are typically dose-independent and unpredictable. Human leukocyte antigens (or HLA) play a central role in the immune reaction by initiating an immune response by presenting antigen to the T-cell receptor. The HLA genes are located at the major histocompatibility complex (MHC) region on chromosome 6 (6p21.3), which contains about 200 genes including more than 10 highly polymorphic HLA genes.

Leukocyte Antigens and Drug Hypersensitivity


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