The Use of Genetics in Guiding Therapy

Mayo Tests for UGT1A1

June 2012

Mayo Medical Laboratories offers 3 tests involving UGT1A1 genetic analysis. The first, UGT1A1 TA Repeat Genotype, analyzes the promoter specifically for the TA repeat region. The second test, UGT1A1 gene sequence, irinotecan, is a sequence analysis of the entire UGT1A1 gene, including the promoter region. Both of these tests can be used to aid in determining an individual’s potential hypersensitivity response to irinotecan. The third test, UGT1A1 gene sequence, hyperbilirubinemia is a sequence analysis of the entire UGT1A1 gene, including the promoter region. This test is useful in the evaluation of individuals with unconjugated hyperbilirubinemia to determine if there is a genetic basis for their high bilirubin levels. A fourth UGT1A1 test is also available but not listed here. This test is the UGT1A1 Known Mutation test and is mainly used for patients who would like to be tested for a known familial UGT1A1 mutation. More information about all of these tests can be found on the Mayo Medical Laboratories website.

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Mayo Tests for UGT1A1

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• Introduction
• Pharmacogenomics
• PGx Biomarkers in Drug Labels
• FDA-Approved Drugs with PGx-Related Label Information
• FDA-Approved Drugs with PGx-Related Label Information
• The FDA and PGx-Related Drug Label Updates
• Clopidogrel (Plavix)
• CYP2C19 and Response to Clopidogrel
• CYP2C19 and Response to Clopidogrel (cont)
• CYP2C19 PGx Testing for Clopidogrel
• Mayo CYP2C19 Test
• The FDA and PGx-Related Drug Label Updates
• Warfarin
• Warfarin PGx
• Allele Frequencies
• Medco-Mayo Warfarin Effectiveness Study
• Mayo Test for Warfarin Sensitivity
• FDA-Approved Drugs with PGx-Related Label Information
• Most Psychotropic Medications Are Metabolized by CYPs
• CYP450 Testing — Psychotherapeutics
• CYP2D6
• Mayo Test for CYP2D6
• Mayo Tests for CYP2D6
• Additional Mayo Tests for Psychiatric Applications
• The FDA and PGx-Related Drug Label Updates
• UGT1A1
• Irinotecan Metabolism
• UGT1A1 Genetic Variants
• Mayo Tests for UGT1A1
• The FDA and PGx-Related Drug Label Updates
• Human Leukocyte Antigens and Drug Hypersensitivity
• HLA-B*1502
• Mayo Test for HLA-B*1502
• HLA-B*5701
• Mayo Test for HLA-B*5701
• Summary
• Questions