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The Use of Genetics in Guiding Therapy


Slide 21

June 2012

CYP2D6 is involved primarily or substantially in the metabolism of 25% of drugs on the market. CYP2D6 is important for metabolism of TCAs, SSRIs, and antipsychotics. CYP2D6 is a highly polymorphic gene and variation in the gene can lead to phenotypes ranging from poor metabolizer or PM to ultrarapid metabolizer or UM. The phenotype prevalence in Caucasians and other ethnic groups is shown here.



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