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The Use of Genetics in Guiding Therapy



CYP2C19 and Response to Clopidogrel

Slide 8

June 2012

As mentioned in the previous slide, clopidogrel is given as a prodrug. It is metabolized to its active form by CYP2C19 and other enzymes. CYP2C19 has several loss of function alleles, but the two alleles that have been studied the most in relation to clopidogrel are the *2 and *3 alleles, for which you can see their ethnic distribution here. These alleles are associated with lower levels of active metabolite of clopidogrel and a marked decrease in platelet responsiveness to clopidogrel (in other words, higher on-treatment platelet aggregation).

CYP2C19 and Response to Clopidogrel

 


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