Autoantibody Profiles Of Myasthenia Gravis, Thymoma, and Lambert-Eaton Myasthenic Syndrome

MGEA/83370 Myasthenia Gravis (MG) Evaluation, Adult Algorithm

May 2012

The diagnostic algorithms consist of tests that are always done and then additional testing that is done depending on the initial results. As you will see from these algorithms in this and the following slides, this is only undertaken where the initial results are suspicious for a diagnosis of thymoma. The additional testing in that setting is to look for other antibody markers which would support a diagnosis of thymoma. So, the testing that is always performed includes the muscle acetylcholine receptor binding antibody, modulating antibodies, and striational antibody. If the acetylcholine receptor modulating antibody loss is >90% and striational antibody is positive, then the testing is reflexed to ganglionic acetylcholine receptor antibody, GAD65 antibody, the voltage-gated potassium channel antibody, and CRMP-5-IgG testing.

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MGEA/83370 Algorithm

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Jump to section:

• Introduction
• Serological Diagnostic Algorithms
• 'Hot Topic' Points
• What are MG and LES?
• What are MG and LES?
• MG: Clinical Diagnosis
• MG: Neoplastic Accompaniments
• LES: Clinical Diagnosis
• LES: Electromyography (EMG) Findings
• LES: Neoplastic Accompaniments
• Autoantibodies Aiding MG Diagnosis
• Autoantibodies Aiding MG Diagnosis
• Single Assay Detects AChR Modulating and AChR Blocking Antibody
• Serum AChR Modulating Antibody Values and Interpretation
• Reasons to Discontinue Testing for AChR Blocking Antibody
• Striational Antibodies
• Autoantibodies Detected in MG Patients With Thymoma
• Autoantibodies Aiding the Diagnosis of LES
• Autoantibodies Aiding the Diagnosis of LES
• MGEA/83370 Myasthenia Gravis (MG) Evaluation, Adult Algorithm
• MGEP/83371 Myasthenia Gravis (MG) Evaluation, Pediatric Algorithm
• MGETH/83372 Myasthenia Gravis (MG) Evaluation, Thymoma Algorithm
• MGLES/83369 Myasthenia Gravis (MG)/Lambert-Eaton Syndrome (LES) Algorithm
• Summary
• Questions?