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Autoantibody Profiles Of Myasthenia Gravis, Thymoma, and Lambert-Eaton Myasthenic Syndrome

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Autoantibodies Aiding the Diagnosis of LES

Slide 18

May 2012

Testing for antibodies with neuronal calcium channel specificity aids the diagnosis of Lambert-Eaton syndrome. There are 2 types of calcium channel antibodies tested for in the myasthenia gravis/Lambert-Eaton syndrome evaluation, P/Q and N-type. P/Q-type calcium channel antibodies are positive in 95% of non-immunosuppressed patients and 99% of patients with cancer. This distinguishes Lambert-Eaton from myasthenia gravis in the appropriate clinical and electrophysiological context.

Autoantibodies Aiding the Diagnosis of LES

 


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