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Autoantibody Profiles Of Myasthenia Gravis, Thymoma, and Lambert-Eaton Myasthenic Syndrome

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Striational Antibodies

Slide 16

May 2012

Another test that when positive is supportive of a diagnosis of myasthenia gravis is the striational antibody test. This is detected by enzyme immunoassay using a mixture of muscle sarcomeric proteins as antigen. Detection of this antibody supports a clinical diagnosis of acquired myasthenia gravis in immunosuppressed patients. Striational antibody seropositivity supports a diagnosis of thymoma or other neoplasm only when acetylcholine receptor modulating antibody is of >90% loss. Positivity is also detected in other autoimmune diseases such as thyroiditis and pernicious anemia.

Striational Antibodies

 


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