Autoantibody Profiles Of Myasthenia Gravis, Thymoma, and Lambert-Eaton Myasthenic Syndrome

Striational Antibodies

May 2012

Another test that when positive is supportive of a diagnosis of myasthenia gravis is the striational antibody test. This is detected by enzyme immunoassay using a mixture of muscle sarcomeric proteins as antigen. Detection of this antibody supports a clinical diagnosis of acquired myasthenia gravis in immunosuppressed patients. Striational antibody seropositivity supports a diagnosis of thymoma or other neoplasm only when acetylcholine receptor modulating antibody is of >90% loss. Positivity is also detected in other autoimmune diseases such as thyroiditis and pernicious anemia.

< Previous Slide

Striational Antibodies

Next Slide >

 

Jump to section:

• Introduction
• Serological Diagnostic Algorithms
• 'Hot Topic' Points
• What are MG and LES?
• What are MG and LES?
• MG: Clinical Diagnosis
• MG: Neoplastic Accompaniments
• LES: Clinical Diagnosis
• LES: Electromyography (EMG) Findings
• LES: Neoplastic Accompaniments
• Autoantibodies Aiding MG Diagnosis
• Autoantibodies Aiding MG Diagnosis
• Single Assay Detects AChR Modulating and AChR Blocking Antibody
• Serum AChR Modulating Antibody Values and Interpretation
• Reasons to Discontinue Testing for AChR Blocking Antibody
• Striational Antibodies
• Autoantibodies Detected in MG Patients With Thymoma
• Autoantibodies Aiding the Diagnosis of LES
• Autoantibodies Aiding the Diagnosis of LES
• MGEA/83370 Myasthenia Gravis (MG) Evaluation, Adult Algorithm
• MGEP/83371 Myasthenia Gravis (MG) Evaluation, Pediatric Algorithm
• MGETH/83372 Myasthenia Gravis (MG) Evaluation, Thymoma Algorithm
• MGLES/83369 Myasthenia Gravis (MG)/Lambert-Eaton Syndrome (LES) Algorithm
• Summary
• Questions?