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Autoantibody Profiles Of Myasthenia Gravis, Thymoma, and Lambert-Eaton Myasthenic Syndrome

An Update

Single Assay Detects AChR Modulating and AChR Blocking Antibody

Slide 13

May 2012

A single assay detects the acetylcholine receptor modulating and blocking antibody. Both lower the number of surface binding sites for radiolabeled alpha-bungarotoxin. Acetylcholine receptor modulating antibody accelerates endocytosis and degradation of the acetylcholine receptor. Acetylcholine receptor blocking antibody inhibits alpha-bungarotoxin binding to acetylcholine receptors.

Single Assay Detects Antibody


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