Dengue Fever
Laboratory Confirmation of Dengue
May 2012
An additional method that has been used for determination of dengue infection is the detection of antigen and antibody to NS1.
Remember, this is a structural protein which is secreted by all flaviviruses, and is detectable up to 10 days after onset of illness. The NS1 antigen will disappear once seroconversion has occurred in the host.
Both antigen-capture ELISAs and lateral flow-antigen detection methods are used, as well as NS1-specific IgM and IgG assays.
Many commercial assays available, however they are not FDA approved. As a whole, NS1 tests have excellent specificity; although sensitivity may vary (60–90%). Some test formats can be used for serotyping.
Laboratory Confirmation of Dengue |
Jump to section:
- Introduction
- Overview
- Dengue Virus
- Structure of Dengue Virus
- History
- History
- Epidemiology of Dengue
- Vectors of Dengue
- Vectors of Dengue
- Life Cycle of Dengue Virus
- Pathogenesis of Dengue
- Classification of Dengue Disease
- Antibody-Dependent Enhancement (ADE)
- Symptoms of Dengue
- Severe Dengue
- Treatment of Dengue
- Diagnosis of Dengue
- Diagnostic Markers for Dengue
- Laboratory Confirmation of Dengue
- Laboratory Confirmation of Dengue
- Laboratory Confirmation of Dengue
- Laboratory Confirmation of Dengue
- Laboratory Confirmation of Dengue
- Rapid Tests
- Laboratory Confirmation of Dengue
- Future Considerations
- Why Are We Concerned About Dengue?
- Key West, Florida 2009–2010
- Key West, Florida 2009–2010
- Why Re-emergence of Dengue in Florida?
- Summary
- Summary
- Summary
- Summary
- References
- Questions
External
link
PDF
document
Excel
document
Word
document