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Dengue Fever


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Laboratory Confirmation of Dengue

Slide 23

May 2012

An additional method that has been used for determination of dengue infection is the detection of antigen and antibody to NS1.

Remember, this is a structural protein which is secreted by all flaviviruses, and is detectable up to 10 days after onset of illness. The NS1 antigen will disappear once seroconversion has occurred in the host.

Both antigen-capture ELISAs and lateral flow-antigen detection methods are used, as well as NS1-specific IgM and IgG assays.

Many commercial assays available, however they are not FDA approved. As a whole, NS1 tests have excellent specificity; although sensitivity may vary (60–90%). Some test formats can be used for serotyping.

Laboratory Confirmation of Dengue


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