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Dengue Fever



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Laboratory Confirmation of Dengue

Slide 22

May 2012

The IgG ELISA is also available as a confirmatory test, if multiple specimens, collected during the course of disease, are used.

This test uses the same antigens as does the MAC-ELISA, the protein E membrane glycoprotein.

The IgG ELISA can differentiate primary or secondary infections, however you must have both acute and convalescent serum specimens. A negative IgG followed by a positive IgG is indicative of a primary infection. A 4-fold rise between acute and convalescent specimens is indicative of a secondary dengue infection. This assay cannot be used to serotype dengue infections.

Commercial tests are available; but they are not FDA-approved at this time.

Laboratory Confirmation of Dengue

 


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