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Dengue Fever



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Structure of Dengue Virus

Slide 4

May 2012

Dengue is a positive-sense, single-stranded RNA virus which is approximately 11 kilobases in length.

The genome depicted here contains regions encoding the viral capsid (C), the membrane (M), and the envelope (E), as well as 7 nonstructural proteins; labeled NS in the figure.

The capsid, membrane, and envelope are all associated with viral structure and subsequent uptake of virus by host cells.

Envelope glycoproteins are associated with binding to host receptors, agglutination of erythrocytes, development of neutralizing antibody, and immune response.

Each subtype of dengue is 65% genetically related to one another.

This figure is taken from an excellent review from Guzman et al, which is cited in the references at the end of this presentation. I strongly recommend this paper if you are interested in additional information on dengue.

Structure of Dengue Virus

 


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