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Autoimmune Gastrointestinal Dysmotility (AGID) Evaluation

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AGIDE/89886 Algorithm

Slide 14

April 2012

There are 4 situations in which additional testing may be done. I’m going to discuss these from left to right. The first is the immunofluorescence pattern is indeterminate. In this situation there may be an antibody staining pattern suspicious for ANNA-1, but not all of the characteristic features are present. In that setting we will additionally do a paraneoplastic Western blot to look for the characteristic pattern associated with this antibody.  The second setting and the third setting would occur where an antibody pattern suggestive of amphiphysin or CRMP-5 IgG were detected. Then we would confirm the presence of either of these antibodies with recombinant Western blots for the appropriate antibody, either amphiphysin or CRMP-5 IgG.

AGIDE/89886 Algorithm

 


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