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Autoimmune Gastrointestinal Dysmotility (AGID) Evaluation

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AGID Antibody Profile

Slide 11

April 2012

On the next slide I am going to go through the profile and the different antibodies that are tested for. Before I do that, I am just going to briefly mention that there are 3 different types of antibodies tested for. First of all, the neuronal nuclear antibody such as ANNA-1 or antineuronal nuclear antibody type-1 which in the literature is also known as anti-Hu antibody. As mentioned earlier, this is associated with small cell carcinoma. Then another group of antibodies which have specificity for antigens in cytoplasm of neuronal cells or muscle cells. These include CRMP-5, IgG, GAD-65 antibody and striational antibody. Finally, another group of antibodies known as the cation-channel antibodies, include the mentioned ganglionic acetylcholine receptor autoantibody but also antibody targeting muscle acetylcholine receptors, N-type calcium channel antibody and the voltage-gated potassium channel antibody.

AGID Antibody Profile

 


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