HPV and p16 Testing in Oropharyngeal Squamous Cell Carcinoma

HPV and p16 Testing in Oropharyngeal Squamous Cell Carcinoma in Review

March 2012

HPV and p16 Testing in Oropharyngeal Squamous Cell Carcinoma in Review.

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• Objectives
• Outline
• Oropharyngeal Squamous Cell Carcinoma in Review
• Oropharynx Anatomy
• Epidemiology of OPSCC — Demographics
• Epidemiology of OPSCC — Incidence
• Management Strategies in OPSCC
• The Role of HPV and p16 in Oropharyngeal Squamous Cell Carcinoma
• Human Papillomavirus (HPV)
• HPV in OPSCC Oncogenesis — Genome
• HPV in OPSCC Oncogenesis — Pathways
• HPV in OPSCC Oncogenesis — Detection
• Indications for HPV and p16 Testing in Oropharyngeal Squamous Cell Carcinoma
• Prognostic
• Prognostic
• Prognostic
• Diagnostic
• Interpretation of HPV and p16 Testing in Oropharyngeal Squamous Cell Carcinoma
• Interpret the Presence or Absence of HPV
• Don't Jump the Gun
• Polymerase Chain Reaction (PCR)
• DNA In Situ Hybridization
• E6/E7 Messenger Ribonucleic Acid (mRNA)
• P16 Immunohistochemistry
• HPV and p16 Testing in Oropharyngeal Squamous Cell Carcinoma in Review
• Review
• Contact Information
• References
• References
• Questions