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HPV and p16 Testing in Oropharyngeal Squamous Cell Carcinoma

Methodology, Interpretation, and Significance

P16 Immunohistochemistry

Slide 25

March 2012

Most studies have found a strong correlation between p16 immunoreactivity and HPV positivity by PCR or ISH. In other words, p16 has a high level of sensitivity.

On the other hand, p16 can be overexpressed even in the absence of HPV DNA or E6/E7 transcripts. For this reason the specificity remains a weakness.

Naturally, p16 interpretation is by way of light microscopy so the histologic correlation goes without saying.

Lastly, not all but a fair number of immunohistochemistry laboratories offer p16 immunostaining.

P16 Immunohistochemistry


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