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HPV and p16 Testing in Oropharyngeal Squamous Cell Carcinoma

Methodology, Interpretation, and Significance

E6/E7 Messenger Ribonucleic Acid (mRNA)

Slide 24

March 2012

Detecting E6/E7 mRNA transcripts provides exquisite sensitivity and specificity. Moreover, this assay affords tremendous insight into the expression status of oncogenes E6 and E7. The presence of E6 and E7 mRNA transcripts, for all intents and purposes, represents biologically active HPV DNA, regardless of localization.

Relatively new systems allow for examination with the light microscope which grants obvious advantages.

Unfortunately, this can be a cumbersome test to perform and is not available in the vast majority of laboratories on a clinical basis.

E6/E7 mRNA


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