HPV and p16 Testing in Oropharyngeal Squamous Cell Carcinoma

Human Papillomavirus (HPV)

March 2012

Human papillomaviruses are encapsulated, nonenveloped, double-stranded DNA viruses that are members of the Papillomaviridae family. This family has well over 100 subtypes, also known as genotypes. These genotypes have different profiles, including variable tissue trophism and biologic roles in human disease. The different genotypes are broken into low- and high-risk categories. The more common low-risk genotypes are 6 and 11 while the more common high-risk genotypes are 16, 18, 31, and 33. Low-risk genotypes are frequently associated with benign neoplasms such as squamous papillomas; on the other hand, high-risk genotypes are more commonly associated with malignant neoplasms such as squamous cell carcinoma.

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Human Papillomavirus (HPV)

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Jump to section:

• Objectives
• Outline
• Oropharyngeal Squamous Cell Carcinoma in Review
• Oropharynx Anatomy
• Epidemiology of OPSCC — Demographics
• Epidemiology of OPSCC — Incidence
• Management Strategies in OPSCC
• The Role of HPV and p16 in Oropharyngeal Squamous Cell Carcinoma
• Human Papillomavirus (HPV)
• HPV in OPSCC Oncogenesis — Genome
• HPV in OPSCC Oncogenesis — Pathways
• HPV in OPSCC Oncogenesis — Detection
• Indications for HPV and p16 Testing in Oropharyngeal Squamous Cell Carcinoma
• Prognostic
• Prognostic
• Prognostic
• Diagnostic
• Interpretation of HPV and p16 Testing in Oropharyngeal Squamous Cell Carcinoma
• Interpret the Presence or Absence of HPV
• Don't Jump the Gun
• Polymerase Chain Reaction (PCR)
• DNA In Situ Hybridization
• E6/E7 Messenger Ribonucleic Acid (mRNA)
• P16 Immunohistochemistry
• HPV and p16 Testing in Oropharyngeal Squamous Cell Carcinoma in Review
• Review
• Contact Information
• References
• References
• Questions