HPV and p16 Testing in Oropharyngeal Squamous Cell Carcinoma

The Role of HPV and p16 in Oropharyngeal Squamous Cell Carcinoma

March 2012

The Role of HPV and p16 in Oropharyngeal Squamous Cell Carcinoma.

Somewhere in the neighborhood of 85% of people will be infected by HPV during their lifetime. Many of these infections are cleared in the immunocompetent host, as we have learned in cervical disease. With respect to head and neck squamous cell carcinoma, HPV can be isolated in approximately 25% of all cases. Of all head and neck sites, HPV has the strongest etiopathogenic link to the oropharynx—most commonly HPV-16. As mentioned previously, these patients are usually younger, lack a history of significant tobacco and/or alcohol exposure, and possibly partake in "high-risk" sexual practices.

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The Role of HPV and p16

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Jump to section:

• Objectives
• Outline
• Oropharyngeal Squamous Cell Carcinoma in Review
• Oropharynx Anatomy
• Epidemiology of OPSCC — Demographics
• Epidemiology of OPSCC — Incidence
• Management Strategies in OPSCC
• The Role of HPV and p16 in Oropharyngeal Squamous Cell Carcinoma
• Human Papillomavirus (HPV)
• HPV in OPSCC Oncogenesis — Genome
• HPV in OPSCC Oncogenesis — Pathways
• HPV in OPSCC Oncogenesis — Detection
• Indications for HPV and p16 Testing in Oropharyngeal Squamous Cell Carcinoma
• Prognostic
• Prognostic
• Prognostic
• Diagnostic
• Interpretation of HPV and p16 Testing in Oropharyngeal Squamous Cell Carcinoma
• Interpret the Presence or Absence of HPV
• Don't Jump the Gun
• Polymerase Chain Reaction (PCR)
• DNA In Situ Hybridization
• E6/E7 Messenger Ribonucleic Acid (mRNA)
• P16 Immunohistochemistry
• HPV and p16 Testing in Oropharyngeal Squamous Cell Carcinoma in Review
• Review
• Contact Information
• References
• References
• Questions