HPV and p16 Testing in Oropharyngeal Squamous Cell Carcinoma

Epidemiology of OPSCC — Incidence

March 2012

Think about this: the number of cigarette smokers has actually declined in recent years, mostly as a result of dramatic public health efforts and smoking cessation programs. Naturally, one would initially expect the incidence of squamous cell carcinoma of the head and neck to decline as well. It turns out that the incidence has not declined; in fact, the incidence has remained relatively unchanged and some studies suggest that the incidence is actually rising. This phenomenon is considered partly to be a function of the new cohort of patients afflicted by oropharyngeal squamous cell carcinoma.

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Epidemiology of OPSCC — Incidence

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Jump to section:

• Objectives
• Outline
• Oropharyngeal Squamous Cell Carcinoma in Review
• Oropharynx Anatomy
• Epidemiology of OPSCC — Demographics
• Epidemiology of OPSCC — Incidence
• Management Strategies in OPSCC
• The Role of HPV and p16 in Oropharyngeal Squamous Cell Carcinoma
• Human Papillomavirus (HPV)
• HPV in OPSCC Oncogenesis — Genome
• HPV in OPSCC Oncogenesis — Pathways
• HPV in OPSCC Oncogenesis — Detection
• Indications for HPV and p16 Testing in Oropharyngeal Squamous Cell Carcinoma
• Prognostic
• Prognostic
• Prognostic
• Diagnostic
• Interpretation of HPV and p16 Testing in Oropharyngeal Squamous Cell Carcinoma
• Interpret the Presence or Absence of HPV
• Don't Jump the Gun
• Polymerase Chain Reaction (PCR)
• DNA In Situ Hybridization
• E6/E7 Messenger Ribonucleic Acid (mRNA)
• P16 Immunohistochemistry
• HPV and p16 Testing in Oropharyngeal Squamous Cell Carcinoma in Review
• Review
• Contact Information
• References
• References
• Questions