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Bacterial Identification by Matrix-Assisted Laser Desorption Ionization Time of Flight Mass Spectrometry


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MALDI TOF Mass Spectrometry: Limitations

Slide 28

February 2012

There are limitations to matrix-assisted laser desorption ionization time of flight mass spectrometry. No susceptibility information is provided and the technology is not generally useful for direct testing of clinical specimens. Some organisms require repeat analyses, and additional processing. The acceptable score cutoffs vary between studies. Some closely related organisms are not differentiated, and sporulation, not covered in today’s presentation, may challenge identification. The available databases could use improvement. Comparison of data from different companies’ instruments is not feasible. Laboratories acquiring the needed equipment will suffer financial loss on existing equipment. Finally, the available systems are not approved by the United States Food and Drug Administration.

MALDI TOF Mass Spectrometry: Limitations


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