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Clopidogrel Platelet Function Tests

Caveats and Controversies


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Slide 37

December 2011

In summary, there is no perfect test for platelet function. Light transmission aggregometry is the gold standard test but has time and availability limitations. Genetic testing can identify poor metabolizers of clopidogrel, but multiple other factors contribute to the variability in response as well. Prasugrel and ticagrelor are newer medications which are believed to be less affected by genetic polymorphisms, but are more costly. Prasugrel also has some increased risk of bleeding. Clopidogrel may become generic next spring leading to a tremendous decrease in the price of this medication.



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