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Clopidogrel Platelet Function Tests

Caveats and Controversies



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Clopidogrel Metabolism and Genetic Polymorphisms

Slide 27

December 2011

The CYP2C19 gene polymorphisms are thought to account for about 12% of the variability in clopidogrel metabolism. Other genetic polymorphisms also affect the metabolism and these include polymorphisms in the gut, liver and platelets. The ABCB1 polymorphism decreases drug absorption in the duodenum, the CYP2C19*17 polymorphism increases metabolism of clopidogrel, the CYP3A5*3 and other CYP genes polymorphisms influence clopidogrel metabolism and the ADP receptor gene P2RY12 platelet polymorphismdecreases effectiveness of the drug.

Metabolism & Genetic Polymorphisms

 


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