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Clopidogrel Platelet Function Tests

Caveats and Controversies



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Number of Gene Polymorphisms

Slide 26

December 2011

The normal genotype for the CYP2C19 gene is designated as CYP2C19*1. Patients who possess two copies of this have normal metabolism of clopidogrel, which is referred to as extensive metabolism. Most of the polymorphisms of the CYP2C19 gene result in less activity of the enzyme and patients with one copy of the normal genotype and one of the polymorphisms have decreased metabolism of clopidogrel which is called intermediate metabolism. Patients with two copies of the same polymorphism or one copy each of two different polymorphisms may have markedly decreased activity and are known as poor metabolizers. CYP2C19*2 is the most common of the polymorphisms and both CYP2C19*2 and CYP2C19*3 result in no or very little activity of the enzyme produced by that gene.

Number of Gene Polymorphisms

 


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