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Clopidogrel Platelet Function Tests

Caveats and Controversies


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Clopidogrel Metabolism

Slide 25

December 2011

Clopidogrel is a prodrug that is metabolized to the active metabolite in the liver by 2 oxidation steps mainly using the enzyme produced by the CYP2C19 gene, which is part of the cytochrome P450 system. Several polymorphisms of this gene exist which cause patients to have less function (more common) or more function of their enzyme and hence less or more amount of the active drug present within their bloodstreams. Genetic testing is available to determine which polymorphisms are present in the patient’s genes.

Clopidogrel Metabolism


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