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Clopidogrel Platelet Function Tests

Caveats and Controversies


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Light Transmission Platelet Aggregometry Studies (LTA)

Slide 10

December 2011

Light transmission platelet aggregometry (LTA) is the gold standard of platelet function testing. It has been used for several decades for detecting hereditary platelet abnormalities such as Bernard Soulier syndrome, Glanzmann’s thrombasthenia and von Willebrand disease. Because it is time and labor intensive, it is seldom used for monitoring resistance to clopidogrel. Testing is most accurate when the patient stops using all medications prior to collection, particularly any anticoagulants. This is true of all platelet function testing (except the specific drug when testing for resistance) and is not always possible due to the patient’s co-morbidities.

LTA Studies


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