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Clopidogrel Platelet Function Tests

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Platelet Function Tests for the Detection of Clopidogrel Resistance

Slide 4

December 2011

The Platelet Function Analyzer or PFA-100 measures the blockage of a membrane coated with collagen and ADP by platelets, mimicking damaged endothelium. Plateletworks is a unique method that utilizes a special ADP tube which is run through the laboratory’s regular CBC impedance analyzer; the platelet count result from this tube is then compared to the patient’s platelet count from a routine EDTA tube which is run immediately prior to the special ADP tube. The Impact cone and plate(let) analyzer has only recently become available for commercial use and measures the amount of stained surface area and average size of platelet aggregates coating a special thrombogenic plate. Thromboelastography has been available for years, but its use for platelet mapping is much more recent. The RoTEM is a newer rotational form of thromboelastography which has been recently introduced to the U.S.  The last test uses detection of the downstream effect of ADP receptor stimulation by measuring the amount of phosphorylated vasodilator-stimulated phosphoprotein using flow cytometry.

Platelet Function Tests


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