Evaluation of Prosthetic Implant Degradation

Background

December 2011

More than 1 million total hip replacements are surgically inserted worldwide each year, with patients benefitting by improved mobility and quality of life. However, implant-specific local and systemic adverse effects related to sensitivity to the metal or due to the wear of the metal surfaces themselves, called adverse reaction to metal debris, or ARMD, affect a small number of implant recipients. Serum chromium and cobalt concentrations correlate with ARMD.

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Jump to section:

• Introduction
• Orthopedic Prostheses
• Background
• Patient Workup
• Issues of Concern
• Metal-on-Metal Wear-Induced Tissue Necrosis
• Metal-on-Metal Wear-Induced Tissue Necrosis
• Effect of Metallosis
• Initial Conclusions
• Interpretive Values
• Are These Concentrations Toxic?
• Are These Concentrations Toxic?
• Specimen Collection
• Metal-Free Blood Tubes
• Summary
• References/Additional Reading
• Questions?
• Disclosure (Dr. Sierra)
• Disclosure (Dr. Moyer)