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The Classic Myeloproliferative Neoplasms

Optimizing Laboratory Testing for Hematologic Disorders Series

Conclusion #3 — MPL Exon 10 Sequencing

Slide 26

October 2011

Our third conclusion today: Only selective patients with possible MPNs should be sequenced for a MPL mutation. Physicians will frequently order MPL exon 10 sequencing when it is not needed in the evaluation of a patient with a possible myeloproliferative neoplasm. And finally, MPL exon 10 sequencing should be limited to patients with negative JAK2 studies and borderline bone marrow morphologic studies as we have talked about previously.

Conclusion #3 — MPL Exon 10 Sequencing


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