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The Classic Myeloproliferative Neoplasms

Optimizing Laboratory Testing for Hematologic Disorders Series



MPL Exon 10 Sequencing: When to Use

Slide 23

October 2011

MPL exon 10 sequencing is primarily useful in those borderline bone marrow cases in which the morphology cannot confidently distinguish between a benign and a myeloproliferative diagnosis. For example, a bone marrow where there is a question of a possible essential thrombocythemia. Frequently, these are cases with thrombocytosis, but without megakaryocyte clusters or only slight megakaryocyte atypia. A second common scenario, is it a possible primary myelofibrosis? The marrow may appear slightly fibrotic but without any megakaryocyte clusters and, again, at best, only slight megakaryocyte atypia. Another possible situation where MPL exon 10 sequencing studies may be useful in peripheral blood studies is if a bone marrow procedure is not feasible–but realizing that this is a low return assay in this situation.

Exon 10 Sequencing: When to Use

 


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