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The Classic Myeloproliferative Neoplasms

Optimizing Laboratory Testing for Hematologic Disorders Series



MPL Exon 10 Sequencing Studies: Background

Slide 21

October 2011

The final topic today regards MPL exon 10 sequencing studies. As background, MPL exon 10 mutations are relatively infrequent and have been identified in approximately 10% of primary myelofibrosis and about 5% of ET patients, while rarely being identified in PV and never in CML. MPL mutations are only rarely present with JAK2 mutations and, in general, MPL mutations are not associated with significant clinical findings or outcomes that would affect the clinical management of those patients.

Exon 10 Sequencing Studies: Background

 


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