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The Classic Myeloproliferative Neoplasms

Optimizing Laboratory Testing for Hematologic Disorders Series

JAK2 V617F at Mayo Clinic

Slide 14

October 2011

Those negative discrepant cases all had very low mutation burdens just below the normal cutoff value and, conversely, the positive discrepant cases had a very low level of positivity just above the normal cutoff value, so basically all had very similar results. The bone marrow diagnoses in these 4 discrepant cases included 1 case of a myelodysplastic/myeloproliferative disorder that was unclassified and 3 cases in which the bone marrow showed no features of myeloid malignancy. Our findings confirmed that either a low-level positive or negative JAK2 result had no impact on the clinical management or outcome of these 4 patients.

JAK2 V617F at Mayo Clinic


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