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The Classic Myeloproliferative Neoplasms

Optimizing Laboratory Testing for Hematologic Disorders Series



Important Laboratory Assays in the MPNs

Slide 9

October 2011

The diagnosis of a myeloproliferative neoplasm requires a multidisciplinary approach including the correlation of clinical findings, CBC and differential count, serum erythropoietin, and bone marrow morphology. Today’s standard practice of care also requires chromosome karyotype, BCR/ABL–whether done by RT-PCR or by FISH to exclude the diagnosis of chronic myelogenous leukemia, JAK2 V617F point mutation analysis, JAK2 exons 12 to 14 sequencing, and MPL exon 10 sequencing studies. The focus of today’s presentation will be on these 3 latter laboratory assays: JAK2 V617F and whether those studies should be done in peripheral blood or bone marrow, JAK2 exon 12 sequencing studies, and MPL exon 10 sequencing studies.

Important Laboratory Assays in the MPNs

 


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