Fecal Occult Blood Testing

CRC Screening by FOBTs

October 2011

So, let’s compare fecal blood test features for the application of colorectal cancer screening. Both sensitive guaiac and FIT tests achieve moderate sensitivity for cancer of >60% but FIT does so, as I mentioned previously, with a single test per patient screen. No test detected advanced adenomas well. FIT generally yields not only the highest sensitivity, but the highest specificities, and uniquely requires no diet or medication restriction. Finally, because of its numerical reporting, the result comes out objectively. Because HemoQuant detects upper GI bleeding so well, it yields lower specificity for colorectal cancer screening and is not recommended for this application.

< Previous Slide

CRC Screening by FOBTs

Next Slide >

 

Jump to section:

• Introduction
• Occult Gastrointestinal (GI) Bleeding: Definition
• Quantity of GI Bleeding Required to "See" Blood in Stool
• Fecal Occult Blood Tests
• Why Detect Occult GI Bleeding?
• Causes of Fe Deficiency in Industrialized Countries (Average %)
• Causes of Occult GI Bleeding
• Fecal Detection of Ingested Blood
• Iron Deficiency or Anemia: Which Test?
• CRC Screening: Target Lesions
• Occult Bleeding From Colorectal Cancer
• Fecal Blood Testing for Colorectal Cancer (CRC)
• FOBT Screening
• Stool Test Detection of CRN in Screen Setting
• Laboratory Testing vs Office Digital Rectal Exam (DRE)
• Evaluation of Fecal Immunochemical Testing (FIT) Assays
• FIT Specificity
• CRC Screening by FOBTs
• CRC Screening Guidelines*
• CRC Screening: Which Fecal Blood Test?
• Soft Indications for FOBT Use?
• Fecal Occult Blood Tests Summary
• Mayo Medical Laboratories Tests
• Questions?
• Disclosures