Fecal Occult Blood Testing
In the screening setting when fecal blood tests are compared against colonoscopy as the gold standard, both FIT and sensitive guaiac tests (such as HemoccultSENSA) do moderately well in detecting colorectal cancers. Detection rates can exceed 60%. However, the standard Hemoccult test detects cancer at much lower rates. It is important to emphasize that the FIT test achieved this sensitivity with just a single test per screen whereas the guaiac test did so with 3 tests per screen. All tests perform poorly in detecting advanced adenomas, which typically do not bleed, with sensitivities of 20% or less. Early stage cancer detection can reduce cancer mortality, but it requires detection of precancers in order to prevent cancer or reduce cancer incidence.
Fecal Blood Testing for CRC
Jump to section:
- Occult Gastrointestinal (GI) Bleeding: Definition
- Quantity of GI Bleeding Required to "See" Blood in Stool
- Fecal Occult Blood Tests
- Why Detect Occult GI Bleeding?
- Causes of Fe Deficiency in Industrialized Countries (Average %)
- Causes of Occult GI Bleeding
- Fecal Detection of Ingested Blood
- Iron Deficiency or Anemia: Which Test?
- CRC Screening: Target Lesions
- Occult Bleeding From Colorectal Cancer
- Fecal Blood Testing for Colorectal Cancer (CRC)
- FOBT Screening
- Stool Test Detection of CRN in Screen Setting
- Laboratory Testing vs Office Digital Rectal Exam (DRE)
- Evaluation of Fecal Immunochemical Testing (FIT) Assays
- FIT Specificity
- CRC Screening by FOBTs
- CRC Screening Guidelines*
- CRC Screening: Which Fecal Blood Test?
- Soft Indications for FOBT Use?
- Fecal Occult Blood Tests Summary
- Mayo Medical Laboratories Tests