Fecal Occult Blood Testing
As mentioned earlier, detection of upper GI bleeding differs dramatically by type of fecal blood test used. Based on recovery of ingested blood (simulating upper GI bleeding), only the HemoQuant test proves to be reliable. With simulated bleeding rates of over 15 mL/day (3 times the amount required to produce iron deficiency or anemia), FIT remains negative. In contrast, HemoQuant detected 100% of that level of bleeding. Based on correlation with HemoQuant tests in patients, >150 mL blood/day is required for upper GI bleeding to be reliably detected by the FIT test. As upper GI bleeding is the most common cause of iron deficiency, it is especially important that the tool used is capable of sensitive detection of upper GI bleeding.
Fecal Detection of Ingested Blood
Jump to section:
- Occult Gastrointestinal (GI) Bleeding: Definition
- Quantity of GI Bleeding Required to "See" Blood in Stool
- Fecal Occult Blood Tests
- Why Detect Occult GI Bleeding?
- Causes of Fe Deficiency in Industrialized Countries (Average %)
- Causes of Occult GI Bleeding
- Fecal Detection of Ingested Blood
- Iron Deficiency or Anemia: Which Test?
- CRC Screening: Target Lesions
- Occult Bleeding From Colorectal Cancer
- Fecal Blood Testing for Colorectal Cancer (CRC)
- FOBT Screening
- Stool Test Detection of CRN in Screen Setting
- Laboratory Testing vs Office Digital Rectal Exam (DRE)
- Evaluation of Fecal Immunochemical Testing (FIT) Assays
- FIT Specificity
- CRC Screening by FOBTs
- CRC Screening Guidelines*
- CRC Screening: Which Fecal Blood Test?
- Soft Indications for FOBT Use?
- Fecal Occult Blood Tests Summary
- Mayo Medical Laboratories Tests