Chromosomal Microarray Testing
In Patients with Development Delay, Autism or other Congenital Anomalies
The ISCA Consortium
September 2011
The goals of this consortium include improving the overall clinical utility of microarray testing by providing evidence-based standards for array design, agreeing on standards for the interpretation of results, and creating a public database of test results with clinical information which will serve as a resource for laboratories, researchers, and clinicians. This database is called the ISCA Clinical CNV Database and contains data generated through routine clinical testing in ISCA member laboratories. All data is completely deidentified. It is contained at NCBI in the database for genomic structural variation (dbVar) and can currently be accessed via the ISCA website. Membership in the consortium is free and individual clinicians are encouraged to join.
The ISCA Consortium |
Jump to section:
- Introduction
- History of Cytogenetic Testing
- History of Cytogenetic Testing
- Chromosomal Microarray Testing
- Chromosomal Microarray Data
- 180K Oligonucleotide Microarray
- Limitations of Chromosomal Microarray
- Human Copy Number Variation (CNV)
- Interpretation of Results
- When to Order a Microarray?
- Additional ACMG Recommendations
- Pretest Counseling
- Pretest Counseling
- Post-Test Follow-Up
- Post-Test Follow-Up
- Post-Test Follow-Up
- The International Standards for Cytogenomic Arrays (ISCA) Consortium
- The ISCA Consortium
- Providing Clinical Information
- Conclusions
- Mayo Clinic Cytogenetics Laboratory
- Questions?
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