The Role of the Laboratory in the Diagnosis of Rheumatoid Arthritis
Diagnostic Performance of Anti-Citrulline Antibodies
August 2011
After the discovery of these antibodies, various studies were performed to determine if they would be an improvement over rheumatoid factor as a diagnostic marker for rheumatoid arthritis.
The initial studies done using indirect immunofluorescence indicated that the antibodies lacked sensitivity in comparison to rheumatoid factor, generally being around 40 to 50% sensitive.
However, the specificity of these antibodies was a clear improvement, being above 95% in most studies.
Diagnostic Performance |
Jump to section:
- Introduction
- Introduction to Rheumatoid Arthritis
- Risk Factors Associated with Development of Rheumatoid Arthritis
- Clinical Symptoms of Rheumatoid Arthritis
- 1987 Classification Criteria for Rheumatoid Arthritis
- 2010 Classification Criteria for Rheumatoid Arthritis
- Laboratory Evaluation of Patient with RA
- Utility of Rheumatoid Factor
- Discovery of Anti-Citrulline Antibodies
- Enzymatic Process of Citrullination
- Diagnostic Performance of Anti-Citrulline Antibodies
- Development of Clinical Assays for Anti-Citrullinated Protein Antibodies
- Development of Clinical Assays for Anti-Citrullinated Protein Antibodies
- Sensitivity and Specificity Comparison Anti-CCP and RF
- Summary
- Questions?
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