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The Role of the Laboratory in the Diagnosis of Rheumatoid Arthritis

Diagnostic Performance of Anti-Citrulline Antibodies

Slide 11

August 2011

After the discovery of these antibodies, various studies were performed to determine if they would be an improvement over rheumatoid factor as a diagnostic marker for rheumatoid arthritis.

The initial studies done using indirect immunofluorescence indicated that the antibodies lacked sensitivity in comparison to rheumatoid factor, generally being around 40 to 50% sensitive.

However, the specificity of these antibodies was a clear improvement, being above 95% in most studies.

Diagnostic Performance


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