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The Role of the Laboratory in the Diagnosis of Rheumatoid Arthritis

Enzymatic Process of Citrullination

Slide 10

August 2011

Citrullination is an enzymatic process that results in a post-translational modification of arginine residues that are found in protein molecules. This process is mediated by peptidyl arginine deiminase. In the presence of calcium, a positively charged arginine residue is deiminated by the enzyme, ultimately releasing ammonia and forming a neutral amino acid referred to as citrulline. It has been demonstrated by numerous groups that the antibodies originally characterized as anti-perinuclear factor, anti-keratin antibodies, and anti-Sa antibodies are all specific for the citrullinated form of a variety of proteins.

Enzymatic Process of Citrullination


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