The Role of the Laboratory in the Diagnosis of Rheumatoid Arthritis
Clinical Symptoms of Rheumatoid Arthritis
August 2011
As far as the clinical features of rheumatoid arthritis are concerned, in most individuals, the disease begins with articular manifestations, generally as a symmetric arthritis. This process begins with inflammation in the synovial joint. Ultimately, without adequate treatment, the disease may progress to erosion and destruction of the cartilage and bone within the joint. In some patients, the disease progresses beyond the joint.
Probably the most common extra-articular manifestations are generally systemic in nature, with patients complaining of fever, fatigue, and unintentional weight loss.
For some patients, the disease will go on to affect other organ systems. I won’t go through each manifestation individually, but as you can see, almost any organ system can be affected, with the clinical consequences being potentially severe for the patient.
Clinical Symptoms of Rheumatoid Arthritis |
Jump to section:
- Introduction
- Introduction to Rheumatoid Arthritis
- Risk Factors Associated with Development of Rheumatoid Arthritis
- Clinical Symptoms of Rheumatoid Arthritis
- 1987 Classification Criteria for Rheumatoid Arthritis
- 2010 Classification Criteria for Rheumatoid Arthritis
- Laboratory Evaluation of Patient with RA
- Utility of Rheumatoid Factor
- Discovery of Anti-Citrulline Antibodies
- Enzymatic Process of Citrullination
- Diagnostic Performance of Anti-Citrulline Antibodies
- Development of Clinical Assays for Anti-Citrullinated Protein Antibodies
- Development of Clinical Assays for Anti-Citrullinated Protein Antibodies
- Sensitivity and Specificity Comparison Anti-CCP and RF
- Summary
- Questions?
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